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Chilean scientists working on developing the first vaccine against alcoholism, based on a genetic mutation present in 20% of the Asian population that naturally suffer the consequences so severe that it inhibits alcohol addiction, said the chief doctor of the project. Thursday, January 13, 2011
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These populations lack a gene that produces the enzyme "aldehyde dehydrogenase", which breaks down alcohol in the body. Without this enzyme, drinking is a reaction so strong that people do not taste the alcohol, explained the doctor at the University of Chile
"The therapy has already been tested in rats genetically alcoholic, which is able to reduce addiction by more than 50% and one or two years will begin human trials," said Asensio.
"If results in humans are as successful as what we observed in animals would suffice if the patient is injected once a month to start feeling the symptoms for an extended period, which deactivate addiction, "he added.
The vaccine is to induce mutations in liver cells through a virus that transmits the genetic information.
operates under the same principle on which are drawn the
patches and pills currently used to control alcohol addiction, but their efficiency would be greater because, unlike the above formulas will not depend on the immediate patient and has fewer side effects. After demonstrating its active principle, scientists are now working to grow the cells needed to produce the virus in reactors and in large quantities. Then comes the stage of optimizing the production, purifying the virus and approval by various committees of ethics and public health institutes.
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